National Institutes of Health Center for Translational Therapeutics
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Molecular Libraries Program

Overview

Docking model of DL-dopa in APE1 (Apurinic/apyrimidinic Endonuclease 1) binding pocketThe Molecular Libraries Program (MLP) is an NIH Common Fund Initiative. Through one of the MLP components, the Molecular Libraries Probe Production Centers Network (MLPCN), biomedical researchers gain access to the large-scale small molecule screening capacity, along with medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways. These chemical probes may also be used in developing of new drugs.

The NCTT is one of the Comprehensive Centers (NCGC) funded by the MLP.

The activities of the MLP in NCTT are conducted in the Probe Development Branch. The scientists in this branch conduct research in high-throughput assay development and screening, informatics and modeling, and analytical and medicinal chemistry. All projects conducted in the MLPCN program at NCTT are highly collaborative and interactive.

See all related projects for the NCTT MLPCN (NCGC) Program

See Staff in the Probe Development Branch

Other members of the MLPCN are listed below.

  • Broad Institute Comprehensive Screening Center
  • Sanford Burnham Center for Chemical Genomics
  • The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps
  • Johns Hopkins Ion Channel Center
  • University of New Mexico Center for Molecular Discovery
  • Southern Research Specialized Biocontainment Screening Center
  • Kansas Specialized Chemistry Center
  • Vanderbilt Specialized Chemistry Center
  • See all related projects for the Molecular Libraries Program

    For more information on the MLPCN and related programs, please see: Molecular Libraries Program [mli.nih.gov]

    To apply for MLPCN resources, please see: Access MLPCN Resources

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    Last Updated: August 3, 2011