NCTT Pharmaceutical Collection
The NCTT Pharmaceutical Collection (NPC) is a comprehensive, publically-accessible collection of approved and investigational drugs for high-throughput screening that provides a valuable resource for both validating new models of disease and better understanding the molecular basis of disease pathology and intervention. The NPC has already generated several useful probes for studying a diverse cross section of biology, including novel targets and pathways.
NCTT provides access to its set of approved drugs and bioactives through the Therapeutics for Rare and Neglected Diseases (TRND) program and as part of the compound collection for the Tox21 initiative, a collaborative effort for toxicity screening among several government agencies including the US Environmental Protection Agency (EPA), the National Toxicology Program (NTP), the US Food and Drugs Administration (FDA), and the NCGC.
Of the nearly 2750 small molecular entities that have been approved for clinical use by US (FDA), EU (EMEA), Japanese (NHI), and Canadian (HC) authorities and that are amenable to HTS screening, we currently possess 2400 as part of our screening collection. Obtaining an authoritative listing of approved drugs was surprisingly difficult. Once obtained, the list was reduced to a non-redundant set of HTS-compatible molecular entities for sourcing.
The current collection was sourced from a combination of traditional chemical suppliers, specialty collections, pharmacies and custom synthesis. All data generated through this effort will be deposited without restriction into PubChem, including the full concentration-response profile of each compound in each assay. Detailed information on the sourcing of this collection including regulatory status, supplier information, compound structures, target information and indication will be made available as time permits. As we complete this initial phase of building a definitive set of pharmaceutical compounds, we plan to expand the collection to include other compounds which target novel diseases, pathways, and classes of proteins in addition to active metabolites of known drugs.
Software
To provide electronic access to the NPC content, we have built a dedicated browser with searching and exporting capabilities. The NPC browser is currently still early in its development cycle. We plan to make regular updates to the browser as we continue to improve on the features and content. Below is a quick preview of the NPC browser.
The latest version of the NPC browser for various platforms can be downloaded from: http://tripod.nih.gov/npc/.
Please let us know if your platform is not listed.
Contact
Please send comments and/or suggestions related to the NPC browser to Drs. Ruili Huang and Noel Southall. For all other inquiries, please contact Dr. Chris Austin.
Last Updated: August 19, 2011
