National Institutes of Health Center for Translational Therapeutics
NCTT is now part of the NIH National Center for Advancing Translational Sciences (NCATS). Content on this site will move to NCATS.NIH.GOV
The mission of the National Institutes of Health Center for Translational Therapeutics (NCTT) is to translate fundamental research into patient treatments by establishing creative partnerships and developing innovative approaches to advance the science of drug discovery.

Translational Therapeutics Pipeline

An illustration in the shape of a pipeline. Click for more details.
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Welcome to NCTT

Scientific Director, Dr. Christopher Austin gives a brief introduction to the NCTT research mission and how researchers can collaborate with the center on drug development projects.

NCTT Operational Model

The NIH Center for Translational Therapeutics (NCTT) is an intramural research laboratory within the NIH with a unique operational model. We conduct research, bring scientific enhancements, and incorporate value to high risk - high reward extramural drug development projects across the therapeutic pipeline. Our research projects are all defined by collaborations and partnerships with investigators and organizations outside our research lab.

NCTT does this through a variety of Scientific Programs.  NCTT programs are supported by a number of sources, including gifts or grants through government intra-agency agreements, non-profit foundations and organizations, and the private sector.  Each program provides resources to facilitate collaborative Research Projects on specific disease research studies.  Each Project has a specific project plan that defines the collaboration, the resources and expertise needed, the timeline, milestones, and deliverables, as well as  go/no go decision points. Outcomes and Resources are the deliverables of our projects and collaborations. They are tangible resources, such as probes or an assay, or outcomes, such as a new technology or process to improve upon the route of translating a disease gene or protein discovery to a treatment.